Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts.

Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells.

The current study examined the signal transduction steps involved in the selective release of arachidonic acid (AA) induced by the addition of secretory phospholipase A2 (sPLA2) isotypes to bone marrow-derived mast cells (BMMC). Overexpression of sPLA2 receptors caused a marked increase in AA and PGD2 release after stimulation of BMMC, implicating sPLA2 receptors in this process. The hypothesis...

Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction.

Neurotransmitters, hormones, cytokines, growth factors and other ligands transmit their specific messages by binding to receptor molecules on the cell surface. The ligand-bound receptors activate effector systems such as adenylate cyclase, cyclic nueleotide phosphodiesterase, ion channels, and phospholipases via membrane-associated transducing systems to generate second messengers. Receptors ac...

Interleukin-6 and phospholipase A2 in sepsis.

Glucocorticoids suppress basal (but not interleukin-1-supported) ovarian phospholipase A2 activity: evidence for glucocorticoid receptor-mediated regulation.

Ovulation may constitute a cyclic, inflammatory-like process, wherein the increased expression of interleukin (IL)-1 and the biosynthesis of prostaglandins may be established corollaries. In this communication we hypothesize that glucocorticoids, potent anti-inflammatory principles, may exert an antiovulatory effect by interfering with ovarian IL-1-driven prostaglandin biosynthesis. To test thi...

Dendritic-cell activation by secretory phospholipase A2.

Dendritic cells (DCs), also referred to as the sentinels of the immune system, induce and coordinate important functions of immune surveillance. DCs acquire immunity-initiating capacity only after a process of maturation usually induced by ligands that bind to members of the tumor necrosis factor (TNF) or toll-like receptor families. Secretory phospholipase A2 (sPLA2), which hydrolyzes the sn-2...